Histone deacetylase inhibitor LMK235 attenuates vascular constriction and aortic remodelling in hypertension

Here, we report that LMK235, a class I and histone deacetylase (HDAC6)‐preferential HDAC inhibitor, reduces hypertension via inhibition of vascular contraction and vessel hypertrophy. Angiotensin II‐infusion mice and spontaneously hypertensive rats (SHRs) were used to test the anti‐hypertensive effe...

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Détails bibliographiques
Publié dans:J Cell Mol Med
Auteurs principaux: Choi, Sin Young, Kee, Hae Jin, Sun, Simei, Seok, Young Mi, Ryu, Yuhee, Kim, Gwi Ran, Kee, Seung‐Jung, Pflieger, Marc, Kurz, Thomas, Kassack, Matthias U., Jeong, Myung Ho
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2019
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433685/
https://ncbi.nlm.nih.gov/pubmed/30734467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14188
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