Molecular mechanisms of heparin-induced modulation of human interleukin 12 bioactivity

Human interleukin-12 (hIL-12) is a heparin-binding cytokine whose activity was previously shown to be enhanced by heparin and other sulfated glycosaminoglycans. The current study investigated the mechanisms by which heparin increases hIL-12 activity. Using multiple human cell types, including natura...

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Vydáno v:J Biol Chem
Hlavní autoři: Nguyen, Khue G., Gillam, Francis B., Hopkins, Jared J., Jayanthi, Srinivas, Gundampati, Ravi Kumar, Su, Guowei, Bear, Jenifer, Pilkington, Guy R., Jalah, Rashmi, Felber, Barbara K., Liu, Jian, Thallapuranam, Suresh Kumar, Zaharoff, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433073/
https://ncbi.nlm.nih.gov/pubmed/30670588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006193
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