Effect of extension of the heparin binding pocket on the structure, stability, and cell proliferation activity of the human acidic fibroblast growth factor

Acidic human fibroblast growth factor (hFGF1) plays a key role in cell growth and proliferation. Activation of the cell surface FGF receptor is believed to involve the glycosaminoglycan, heparin. However, the exact role of heparin is a subject of considerable debate. In this context, in this study,...

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Veröffentlicht in:Biochem Biophys Rep
Hauptverfasser: Davis, Julie Eberle, Gundampati, Ravi Kumar, Jayanthi, Srinivas, Anderson, Joshua, Pickhardt, Abigail, Koppolu, Bhanu prasanth, Zaharoff, David A., Kumar, Thallapuranam Krishnaswamy Suresh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857160/
https://ncbi.nlm.nih.gov/pubmed/29556563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2017.12.001
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