Efficient production and purification of recombinant human interleukin-12 (IL-12) overexpressed in mammalian cells without affinity tag

Interleukin-12 is a heterodimeric, pro-inflammatory cytokine that is a key driver of cell-mediated immunity. Clinical interest in IL-12 is significant due to its potent anti-tumor activity and efficacy in controlling certain infectious diseases such as Leishmaniasis and Listeria infection. For clini...

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Main Authors: Jayanthi, Srinivas, Koppolu, Bhanu prasanth, Smith, Sean G., Jalah, Rashmi, Bear, Jenifer, Rosati, Margherita, Pavlakis, George N., Felber, Barbara K., Zaharoff, David A., Kumar, Thallapuranam Krishnaswamy Suresh
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164965/
https://ncbi.nlm.nih.gov/pubmed/25123642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2014.07.002
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