Molecular mechanisms of heparin-induced modulation of human interleukin 12 bioactivity

Human interleukin-12 (hIL-12) is a heparin-binding cytokine whose activity was previously shown to be enhanced by heparin and other sulfated glycosaminoglycans. The current study investigated the mechanisms by which heparin increases hIL-12 activity. Using multiple human cell types, including natura...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Nguyen, Khue G., Gillam, Francis B., Hopkins, Jared J., Jayanthi, Srinivas, Gundampati, Ravi Kumar, Su, Guowei, Bear, Jenifer, Pilkington, Guy R., Jalah, Rashmi, Felber, Barbara K., Liu, Jian, Thallapuranam, Suresh Kumar, Zaharoff, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433073/
https://ncbi.nlm.nih.gov/pubmed/30670588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006193
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