Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model

Alzheimer's disease (AD) is pathologically characterized by the deposition of the β-amyloid (Aβ) peptide in senile plaques in the brain, leading to neuronal dysfunction and eventual decline in cognitive function. Genome-wide association studies have identified the bridging integrator 1 (BIN1) g...

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Vydáno v:J Biol Chem
Hlavní autoři: Andrew, Robert J., De Rossi, Pierre, Nguyen, Phuong, Kowalski, Haley R., Recupero, Aleksandra J., Guerbette, Thomas, Krause, Sofia V., Rice, Richard C., Laury-Kleintop, Lisa, Wagner, Steven L., Thinakaran, Gopal
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433054/
https://ncbi.nlm.nih.gov/pubmed/30692199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006379
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