The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation

The metabolism of PI(3,5)P2 is regulated by the PIKfyve, VAC14 and FIG4 complex, mutations in which are associated with hypopigmentation in mice. These pigmentation defects indicate a key, but as yet unexplored, physiological relevance of this complex in the biogenesis of melanosomes. Here, we show...

Full description

Saved in:
Bibliographic Details
Published in:J Cell Sci
Main Authors: Bissig, Christin, Croisé, Pauline, Heiligenstein, Xavier, Hurbain, Ilse, Lenk, Guy M., Kaufman, Emily, Sannerud, Ragna, Annaert, Wim, Meisler, Miriam H., Weisman, Lois S., Raposo, Graça, van Niel, Guillaume
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432708/
https://ncbi.nlm.nih.gov/pubmed/30709920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.229500
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items