The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation

The metabolism of PI(3,5)P2 is regulated by the PIKfyve, VAC14 and FIG4 complex, mutations in which are associated with hypopigmentation in mice. These pigmentation defects indicate a key, but as yet unexplored, physiological relevance of this complex in the biogenesis of melanosomes. Here, we show...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Sci
Prif Awduron: Bissig, Christin, Croisé, Pauline, Heiligenstein, Xavier, Hurbain, Ilse, Lenk, Guy M., Kaufman, Emily, Sannerud, Ragna, Annaert, Wim, Meisler, Miriam H., Weisman, Lois S., Raposo, Graça, van Niel, Guillaume
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists Ltd 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432708/
https://ncbi.nlm.nih.gov/pubmed/30709920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.229500
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