The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation

The metabolism of PI(3,5)P2 is regulated by the PIKfyve, VAC14 and FIG4 complex, mutations in which are associated with hypopigmentation in mice. These pigmentation defects indicate a key, but as yet unexplored, physiological relevance of this complex in the biogenesis of melanosomes. Here, we show...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Bissig, Christin, Croisé, Pauline, Heiligenstein, Xavier, Hurbain, Ilse, Lenk, Guy M., Kaufman, Emily, Sannerud, Ragna, Annaert, Wim, Meisler, Miriam H., Weisman, Lois S., Raposo, Graça, van Niel, Guillaume
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432708/
https://ncbi.nlm.nih.gov/pubmed/30709920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.229500
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