The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation

The metabolism of PI(3,5)P2 is regulated by the PIKfyve, VAC14 and FIG4 complex, mutations in which are associated with hypopigmentation in mice. These pigmentation defects indicate a key, but as yet unexplored, physiological relevance of this complex in the biogenesis of melanosomes. Here, we show...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Cell Sci
Päätekijät: Bissig, Christin, Croisé, Pauline, Heiligenstein, Xavier, Hurbain, Ilse, Lenk, Guy M., Kaufman, Emily, Sannerud, Ragna, Annaert, Wim, Meisler, Miriam H., Weisman, Lois S., Raposo, Graça, van Niel, Guillaume
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Company of Biologists Ltd 2019
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432708/
https://ncbi.nlm.nih.gov/pubmed/30709920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.229500
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