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Glycoconjugate synthesis using chemoselective ligation

Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the producti...

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Veröffentlicht in:Org Biomol Chem
Hauptverfasser: Cheng, Shuihong, Wantuch, Paeton L., Kizer, Megan E., Middleton, Dustin R., Wang, Ruitong, DiBello, Mikaela, Li, Mingli, Wang, Xing, Li, Xuebing, Ramachandiran, Vasanthi, Avci, Fikri Y., Zhang, Fuming, Zhang, Xing, Linhardt, Robert J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431789/
https://ncbi.nlm.nih.gov/pubmed/30778481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9ob00270g
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