Spray drying OZ439 nanoparticles to form stable, water-dispersible powders for oral malaria therapy

BACKGROUND: OZ439 is a new chemical entity which is active against drug-resistant malaria and shows potential as a single-dose cure. However, development of an oral formulation with desired exposure has proved problematic, as OZ439 is poorly soluble (BCS Class II drug). In order to be feasible for l...

Full description

Saved in:
Bibliographic Details
Published in:J Transl Med
Main Authors: Ristroph, Kurt D., Feng, Jie, McManus, Simon A., Zhang, Yingyue, Gong, Kai, Ramachandruni, Hanu, White, Claire E., Prud’homme, Robert K.
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431012/
https://ncbi.nlm.nih.gov/pubmed/30902103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1849-8
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items