Solid-State Behavior and Solubilization of Flash Nanoprecipitated Clofazimine Particles during the Dispersion and Digestion of Milk-Based Formulations

[Image: see text] Clofazimine, a drug previously used to treat leprosy, has recently been identified as a potential new drug for the treatment for cryptosporidiosis: a diarrheal disease that contributes to 500 000 infant deaths a year in developing countries. Rapid dissolution and local availability...

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Vydáno v:Mol Pharm
Hlavní autoři: Salim, Malinda, Ramirez, Gisela, Clulow, Andrew J., Zhang, Yingyue, Ristroph, Kurt D., Feng, Jie, McManus, Simon A., Hawley, Adrian, Prud’homme, Robert K., Boyd, Ben J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549212/
https://ncbi.nlm.nih.gov/pubmed/31038976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00276
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