Spray drying OZ439 nanoparticles to form stable, water-dispersible powders for oral malaria therapy

BACKGROUND: OZ439 is a new chemical entity which is active against drug-resistant malaria and shows potential as a single-dose cure. However, development of an oral formulation with desired exposure has proved problematic, as OZ439 is poorly soluble (BCS Class II drug). In order to be feasible for l...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Ristroph, Kurt D., Feng, Jie, McManus, Simon A., Zhang, Yingyue, Gong, Kai, Ramachandruni, Hanu, White, Claire E., Prud’homme, Robert K.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431012/
https://ncbi.nlm.nih.gov/pubmed/30902103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1849-8
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