PI3K Oncogenic Mutations Mediate Resistance to Afatinib In HER2/neu Overexpressing Gynecological Cancers

OBJECTIVE: Aberrant expression of HER2/neu and PIK3CA gene products secondary to amplification/mutations are common in high-grade-serous-endometrial (USC) and ovarian-cancers (HGSOC). Because scant information is currently available in the literature on the potential negative effect of PIK3CA mutati...

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Gepubliceerd in:Gynecol Oncol
Hoofdauteurs: Bonazzoli, Elena, Cocco, Emiliano, Lopez, Salvatore, Bellone, Stefania, Zammataro, Luca, Bianchi, Anna, Manzano, Aranzazu, Yadav, Ghanshyam, Manara, Paola, Perrone, Emanuele, Haines, Kaitlin, Espinal, Mariana, Dugan, Katherine, Menderes, Gulden, Altwerger, Gary, Han, Chanhee, Zeybek, Burak, Litkouhi, Babak, Ratner, Elena, Silasi, Dan-Arin, Huang, Gloria S., Azodi, Masoud, Schwartz, Peter E., Santin, Alessandro D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430698/
https://ncbi.nlm.nih.gov/pubmed/30630630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2019.01.002
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