PI3K Oncogenic Mutations Mediate Resistance to Afatinib In HER2/neu Overexpressing Gynecological Cancers

OBJECTIVE: Aberrant expression of HER2/neu and PIK3CA gene products secondary to amplification/mutations are common in high-grade-serous-endometrial (USC) and ovarian-cancers (HGSOC). Because scant information is currently available in the literature on the potential negative effect of PIK3CA mutati...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Gynecol Oncol
Autori principali: Bonazzoli, Elena, Cocco, Emiliano, Lopez, Salvatore, Bellone, Stefania, Zammataro, Luca, Bianchi, Anna, Manzano, Aranzazu, Yadav, Ghanshyam, Manara, Paola, Perrone, Emanuele, Haines, Kaitlin, Espinal, Mariana, Dugan, Katherine, Menderes, Gulden, Altwerger, Gary, Han, Chanhee, Zeybek, Burak, Litkouhi, Babak, Ratner, Elena, Silasi, Dan-Arin, Huang, Gloria S., Azodi, Masoud, Schwartz, Peter E., Santin, Alessandro D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430698/
https://ncbi.nlm.nih.gov/pubmed/30630630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2019.01.002
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi