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The ribonuclease PARN controls the levels of specific miRNAs that contribute to p53 regulation
PARN loss-of-function mutations cause a severe form of the hereditary disease dyskeratosis congenita (DC). PARN deficiency affects the stability of non-coding RNAs such as human telomerase RNA (hTR), but these effects do not explain the severe disease in patients. We demonstrate that PARN deficiency...
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| Publicado en: | Mol Cell |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6430647/ https://ncbi.nlm.nih.gov/pubmed/30770239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.010 |
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