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PARN Modulates Y RNA Stability and Its 3′-End Formation
Loss-of-function mutations in 3′-to-5′ exoribonucleases have been implicated in hereditary human diseases. For example, PARN mutations cause a severe form of dyskeratosis congenita (DC), wherein PARN deficiency leads to human telomerase RNA instability. Since the DC phenotype in PARN patients is eve...
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| Publicado no: | Mol Cell Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5615183/ https://ncbi.nlm.nih.gov/pubmed/28760775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00264-17 |
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