Antigenicity and Immunogenicity of Differentially Glycosylated Hepatitis C Virus E2 Envelope Proteins Expressed in Mammalian and Insect Cells

The development of a prophylactic vaccine for hepatitis C virus (HCV) remains a global health challenge. Cumulative evidence supports the importance of antibodies targeting the HCV E2 envelope glycoprotein to facilitate viral clearance. However, a significant challenge for a B cell-based vaccine is...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Urbanowicz, Richard A., Wang, Ruixue, Schiel, John E., Keck, Zhen-yong, Kerzic, Melissa C., Lau, Patrick, Rangarajan, Sneha, Garagusi, Kyle J., Tan, Lei, Guest, Johnathan D., Ball, Jonathan K., Pierce, Brian G., Mariuzza, Roy A., Foung, Steven K. H., Fuerst, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430559/
https://ncbi.nlm.nih.gov/pubmed/30651366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01403-18
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