Antigenicity and Immunogenicity of Differentially Glycosylated Hepatitis C Virus E2 Envelope Proteins Expressed in Mammalian and Insect Cells

The development of a prophylactic vaccine for hepatitis C virus (HCV) remains a global health challenge. Cumulative evidence supports the importance of antibodies targeting the HCV E2 envelope glycoprotein to facilitate viral clearance. However, a significant challenge for a B cell-based vaccine is...

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Библиографические подробности
Опубликовано в: :J Virol
Главные авторы: Urbanowicz, Richard A., Wang, Ruixue, Schiel, John E., Keck, Zhen-yong, Kerzic, Melissa C., Lau, Patrick, Rangarajan, Sneha, Garagusi, Kyle J., Tan, Lei, Guest, Johnathan D., Ball, Jonathan K., Pierce, Brian G., Mariuzza, Roy A., Foung, Steven K. H., Fuerst, Thomas R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2019
Предметы:
Vaccines and Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430559/
https://ncbi.nlm.nih.gov/pubmed/30651366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01403-18
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