Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization

An effective vaccine for hepatitis C virus (HCV) is a major unmet need, and it requires an antigen that elicits immune responses to key conserved epitopes. Based on structures of antibodies targeting HCV envelope glycoprotein E2, we designed immunogens to modulate the structure and dynamics of E2 an...

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Vydáno v:J Virol
Hlavní autoři: Pierce, Brian G., Keck, Zhen-Yong, Wang, Ruixue, Lau, Patrick, Garagusi, Kyle, Elkholy, Khadija, Toth, Eric A., Urbanowicz, Richard A., Guest, Johnathan D., Agnihotri, Pragati, Kerzic, Melissa C., Marin, Alexander, Andrianov, Alexander K., Ball, Jonathan K., Mariuzza, Roy A., Fuerst, Thomas R., Foung, Steven K. H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592221/
https://ncbi.nlm.nih.gov/pubmed/32878891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00704-20
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