Hepatocellular Carcinoma Detection by Plasma Methylated DNA: Discovery, Phase I Pilot, and Phase II Clinical Validation

Early detection improves hepatocellular carcinoma (HCC) outcomes, but better noninvasive surveillance tools are needed. We aimed to identify and validate methylated DNA markers (MDMs) for HCC detection. Reduced representation bisulfite sequencing was performed on DNA extracted from 18 HCC and 35 con...

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Bibliographic Details
Published in:Hepatology
Main Authors: Kisiel, John B., Dukek, Brian A., Kanipakam, Reddappa V. S. R., Ghoz, Hassan M., Yab, Tracy C., Berger, Calise K., Taylor, William R., Foote, Patrick H., Giama, Nasra H., Onyirioha, Kristeen, Abdallah, Mohamed A., Burger, Kelli N., Slettedahl, Seth W., Mahoney, Douglas W., Smyrk, Thomas C., Lewis, Jason T., Giakoumopoulos, Maria, Allawi, Hatim T., Lidgard, Graham, Roberts, Lewis R., Ahlquist, David A.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429916/
https://ncbi.nlm.nih.gov/pubmed/30168613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30244
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