Hepatocellular Carcinoma Detection by Plasma Methylated DNA: Discovery, Phase I Pilot, and Phase II Clinical Validation

Early detection improves hepatocellular carcinoma (HCC) outcomes, but better noninvasive surveillance tools are needed. We aimed to identify and validate methylated DNA markers (MDMs) for HCC detection. Reduced representation bisulfite sequencing was performed on DNA extracted from 18 HCC and 35 con...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Kisiel, John B., Dukek, Brian A., Kanipakam, Reddappa V. S. R., Ghoz, Hassan M., Yab, Tracy C., Berger, Calise K., Taylor, William R., Foote, Patrick H., Giama, Nasra H., Onyirioha, Kristeen, Abdallah, Mohamed A., Burger, Kelli N., Slettedahl, Seth W., Mahoney, Douglas W., Smyrk, Thomas C., Lewis, Jason T., Giakoumopoulos, Maria, Allawi, Hatim T., Lidgard, Graham, Roberts, Lewis R., Ahlquist, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429916/
https://ncbi.nlm.nih.gov/pubmed/30168613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30244
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