Fast Methods for Prediction of Aldehyde Oxidase-Mediated Site-of-Metabolism

Aldehyde Oxidase (AO) is an enzyme involved in the metabolism of aldehydes and N-containing heterocyclic compounds. Many drug compounds contain heterocyclic moieties, and AO metabolism has lead to failure of several late-stage drug candidates. Therefore, it is important to take AO-mediated metabolis...

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Bibliographic Details
Published in:Comput Struct Biotechnol J
Main Authors: Montefiori, Marco, Lyngholm-Kjærby, Casper, Long, Anthony, Olsen, Lars, Jørgensen, Flemming Steen
Format: Artigo
Language:Inglês
Published: Research Network of Computational and Structural Biotechnology 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429535/
https://ncbi.nlm.nih.gov/pubmed/30949305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2019.03.003
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