Caricamento...

Predicting Intrinsic Clearance for Drugs and Drug Candidates Metabolized by Aldehyde Oxidase

Metabolism by aldehyde oxidase (AO) has been responsible for a number of drug failures in clinical trials. The main reason is the clearance values for drugs metabolized by AO are underestimated by allometric scaling from preclinical species. Furthermore, in vitro human data also underestimates clear...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Jones, Jeffrey P., Korzekwa, Kenneth R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615103/
https://ncbi.nlm.nih.gov/pubmed/23363487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300568r
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !