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Membrane-Binding Cooperativity and Coinsertion by C2AB Tandem Domains of Synaptotagmins 1 and 7

Synaptotagmin-1 (Syt-1) and synaptotagmin-7 (Syt-7) contain analogous tandem C2 domains, C2A and C2B, which together sense Ca(2+) to bind membranes and promote the stabilization of exocytotic fusion pores. Syt-1 triggers fast release of neurotransmitters, whereas Syt-7 functions in processes that in...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Tran, Hai T., Anderson, Lauren H., Knight, Jefferson D.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428868/
https://ncbi.nlm.nih.gov/pubmed/30795874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.01.035
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