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Hydrophobic Contributions to the Membrane Docking of Synaptotagmin 7 C2A Domain: Mechanistic Contrast Between Isoforms 1 and 7

Synaptotagmin (Syt) triggers Ca(2+)-dependent membrane fusion via its tandem C2 domains, C2A and C2B. The seventeen known human isoforms are active in different secretory cell types, including neurons (Syt1 and others) and pancreatic β cells (Syt7 and others). Here, quantitative fluorescence measure...

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Main Authors: Brandt, Devin S., Coffman, Matthew D., Falke, Joseph J., Knight, Jefferson D.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494482/
https://ncbi.nlm.nih.gov/pubmed/22966849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3007115
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