Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence

The stringent response enables Mycobacterium tuberculosis (Mtb) to shut down its replication and metabolism under various stresses. Here we show that Mtb lacking the stringent response enzyme Rel(Mtb) was unable to slow its replication rate during nutrient starvation. Metabolomics analysis revealed...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Dutta, Noton K., Klinkenberg, Lee G., Vazquez, Maria-Jesus, Segura-Carro, Delfina, Colmenarejo, Gonzalo, Ramon, Fernando, Rodriguez-Miquel, Beatriz, Mata-Cantero, Lydia, Porras-De Francisco, Esther, Chuang, Yu-Min, Rubin, Harvey, Lee, Jae Jin, Eoh, Hyungjin, Bader, Joel S., Perez-Herran, Esther, Mendoza-Losana, Alfonso, Karakousis, Petros C.
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426458/
https://ncbi.nlm.nih.gov/pubmed/30906866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav2104
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