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The stringent response is required for full virulence of Mycobacterium tuberculosis in guinea pigs

During human latent tuberculosis (TB) infection, Mycobacterium tuberculosis likely resides within the nutrient-starved environment of caseous lung granulomas. The stringent response alarmone (p)ppGpp is synthesized by Rel in response to nutrient starvation, thus enabling tubercle bacilli to restrict...

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Bibliografiske detaljer
Main Authors: Klinkenberg, Lee G., Lee, Jong-Hee, Bishai, William R., Karakousis, Petros C.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949470/
https://ncbi.nlm.nih.gov/pubmed/20863231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/656524
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