The Impact of Mouse Passaging of Mycobacterium tuberculosis Strains prior to Virulence Testing in the Mouse and Guinea Pig Aerosol Models

BACKGROUND: It has been hypothesized that the virulence of lab-passaged Mycobacterium tuberculosis and recombinant M. tuberculosis mutants might be reduced due to multiple in vitro passages, and that virulence might be augmented by passage of these strains through mice before quantitative virulence...

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Main Authors: Converse, Paul J., Eisenach, Kathleen D., Theus, Sue A., Nuermberger, Eric L., Tyagi, Sandeep, Ly, Lan H., Geiman, Deborah E., Guo, Haidan, Nolan, Scott T., Akar, Nicole C., Klinkenberg, Lee G., Gupta, Radhika, Lun, Shichun, Karakousis, Petros C., Lamichhane, Gyanu, McMurray, David N., Grosset, Jacques H., Bishai, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858211/
https://ncbi.nlm.nih.gov/pubmed/20422019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010289
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