The Impact of Mouse Passaging of Mycobacterium tuberculosis Strains prior to Virulence Testing in the Mouse and Guinea Pig Aerosol Models

BACKGROUND: It has been hypothesized that the virulence of lab-passaged Mycobacterium tuberculosis and recombinant M. tuberculosis mutants might be reduced due to multiple in vitro passages, and that virulence might be augmented by passage of these strains through mice before quantitative virulence...

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Hlavní autoři: Converse, Paul J., Eisenach, Kathleen D., Theus, Sue A., Nuermberger, Eric L., Tyagi, Sandeep, Ly, Lan H., Geiman, Deborah E., Guo, Haidan, Nolan, Scott T., Akar, Nicole C., Klinkenberg, Lee G., Gupta, Radhika, Lun, Shichun, Karakousis, Petros C., Lamichhane, Gyanu, McMurray, David N., Grosset, Jacques H., Bishai, William R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858211/
https://ncbi.nlm.nih.gov/pubmed/20422019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010289
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