Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence

The stringent response enables Mycobacterium tuberculosis (Mtb) to shut down its replication and metabolism under various stresses. Here we show that Mtb lacking the stringent response enzyme Rel(Mtb) was unable to slow its replication rate during nutrient starvation. Metabolomics analysis revealed...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Dutta, Noton K., Klinkenberg, Lee G., Vazquez, Maria-Jesus, Segura-Carro, Delfina, Colmenarejo, Gonzalo, Ramon, Fernando, Rodriguez-Miquel, Beatriz, Mata-Cantero, Lydia, Porras-De Francisco, Esther, Chuang, Yu-Min, Rubin, Harvey, Lee, Jae Jin, Eoh, Hyungjin, Bader, Joel S., Perez-Herran, Esther, Mendoza-Losana, Alfonso, Karakousis, Petros C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2019
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426458/
https://ncbi.nlm.nih.gov/pubmed/30906866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav2104
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