Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence

The stringent response enables Mycobacterium tuberculosis (Mtb) to shut down its replication and metabolism under various stresses. Here we show that Mtb lacking the stringent response enzyme Rel(Mtb) was unable to slow its replication rate during nutrient starvation. Metabolomics analysis revealed...

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Publicado en:Sci Adv
Autores principales: Dutta, Noton K., Klinkenberg, Lee G., Vazquez, Maria-Jesus, Segura-Carro, Delfina, Colmenarejo, Gonzalo, Ramon, Fernando, Rodriguez-Miquel, Beatriz, Mata-Cantero, Lydia, Porras-De Francisco, Esther, Chuang, Yu-Min, Rubin, Harvey, Lee, Jae Jin, Eoh, Hyungjin, Bader, Joel S., Perez-Herran, Esther, Mendoza-Losana, Alfonso, Karakousis, Petros C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for the Advancement of Science 2019
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426458/
https://ncbi.nlm.nih.gov/pubmed/30906866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav2104
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