Transcriptome and epigenome landscape of human cortical development modeled in brain organoids

Genes implicated in neuropsychiatric disorders are active in human fetal brain, yet difficult to study in a longitudinal fashion. We demonstrate that organoids from human pluripotent cells model cerebral cortical development on the molecular level before 16 weeks post-conception. A multi-omics analy...

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Pubblicato in:Science
Autori principali: Amiri, Anahita, Coppola, Gianfilippo, Scuderi, Soraya, Wu, Feinan, Roychowdhury, Tanmoy, Liu, Fuchen, Pochareddy, Sirisha, Shin, Yurae, Safi, Alexias, Song, Lingyun, Zhu, Ying, Sousa, André M. M., Gerstein, Mark, Crawford, Gregory E., Sestan, Nenad, Abyzov, Alexej, Vaccarino, Flora M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426303/
https://ncbi.nlm.nih.gov/pubmed/30545853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat6720
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