Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat Model

BACKGROUND: The common cytotoxic mechanisms that underpin chemoefficacy and toxicity have hampered efforts to deliver effective supportive care interventions, particularly for gastrointestinal (GI) toxicity. Matrix metalloproteinases (MMPs) have been implicated in both tumor growth and GI toxicity,...

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Detalhes bibliográficos
Publicado no:Chemotherapy
Main Authors: Gibson, Rachel J., van Sebille, Ysabella Z.A., Wardill, Hannah R., Wignall, Anthony, Shirren, Joseph, Ball, Imogen A., Williams, Nicole, Wanner, Kiara, Bowen, Joanne M.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2019
Assuntos:
Anticancer Section / Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6425820/
https://ncbi.nlm.nih.gov/pubmed/30731451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000495470
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