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Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat Model

BACKGROUND: The common cytotoxic mechanisms that underpin chemoefficacy and toxicity have hampered efforts to deliver effective supportive care interventions, particularly for gastrointestinal (GI) toxicity. Matrix metalloproteinases (MMPs) have been implicated in both tumor growth and GI toxicity,...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Chemotherapy
मुख्य लेखकों: Gibson, Rachel J., van Sebille, Ysabella Z.A., Wardill, Hannah R., Wignall, Anthony, Shirren, Joseph, Ball, Imogen A., Williams, Nicole, Wanner, Kiara, Bowen, Joanne M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: S. Karger AG 2019
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6425820/
https://ncbi.nlm.nih.gov/pubmed/30731451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000495470
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