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Irinotecan disrupts tight junction proteins within the gut: Implications for chemotherapy-induced gut toxicity

Chemotherapy for cancer causes significant gut toxicity, leading to severe clinical manifestations and an increased economic burden. Despite much research, many of the underlying mechanisms remain poorly understood hindering effective treatment options. Recently there has been renewed interest in th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wardill, Hannah R, Bowen, Joanne M, Al-Dasooqi, Noor, Sultani, Masooma, Bateman, Emma, Stansborough, Romany, Shirren, Joseph, Gibson, Rachel J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928140/
https://ncbi.nlm.nih.gov/pubmed/24316664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.27222
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