Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues

Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique a...

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Detalhes bibliográficos
Publicado no:Adv Sci (Weinh)
Main Authors: Krüger, Franziska, Kumar, Vipin, Monge, Pere, Conzelmann, Carina, Smith, Nikaïa, Gothelf, Kurt V., Tolstrup, Martin, Münch, Jan, Zelikin, Alexander N.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6425433/
https://ncbi.nlm.nih.gov/pubmed/30937274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201802095
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