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Macromolecular prodrugs of ribavirin: Polymer backbone defines blood safety, drug release, and efficacy of anti-inflammatory effects

Macromolecular (pro)drugs hold much promise as broad-spectrum antiviral agents as either microbicides or carriers for intracellular delivery of antiviral drugs. Intriguing opportunity exists in combining the two modes of antiviral activity in the same polymer structure such that the same polymer act...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Zuwala, Kaja, Riber, Camilla F., Løvschall, Kaja Borup, Andersen, Anna H.F., Sørensen, Lise, Gajda, Paulina, Tolstrup, Martin, Zelikin, Alexander N.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7114659/
https://ncbi.nlm.nih.gov/pubmed/29432822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.02.012
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