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HIV anti-latency treatment mediated by macromolecular prodrugs of histone deacetylase inhibitor, panobinostat

Histone deacetylase inhibitors (HDACi) and panobinostat in particular are currently in the focus of intensive investigation as latency reversing agents against the human immunodeficiency virus (HIV). Regretfully, HDACi have dose limiting side-effects making controlled, optimized methods for delivery...

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Bibliografske podrobnosti
izdano v:Chem Sci
Main Authors: Zuwala, Kaja, Smith, Anton A. A., Tolstrup, Martin, Zelikin, Alexander N.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003675/
https://ncbi.nlm.nih.gov/pubmed/29997778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03257a
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