The Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function

Palmitoyl-protein thioesterase 1 (PPT1) is a depalmitoylation enzyme that is mutated in cases of neuronal ceroid lipofuscinosis (NCL). The hallmarks of the disease include progressive neurodegeneration and blindness, as well as seizures. In the current study, we identified 62 high-confident PPT1-bin...

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Veröffentlicht in:Front Cell Neurosci
Hauptverfasser: Sapir, Tamar, Segal, Michal, Grigoryan, Gayane, Hansson, Karin M., James, Peter, Segal, Menahem, Reiner, Orly
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6424868/
https://ncbi.nlm.nih.gov/pubmed/30918483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00092
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