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Reversible Cysteine Acylation Regulates the Activity of Human Palmitoyl-Protein Thioesterase 1 (PPT1)

Mutations in the depalmitoylating enzyme gene, PPT1, cause the infantile form of Neuronal Ceroid Lipofuscinosis (NCL), an early onset neurodegenerative disease. During recent years there have been different therapeutic attempts including enzyme replacement. Here we show that PPT1 is palmitoylated in...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Segal-Salto, Michal, Sapir, Tamar, Reiner, Orly
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701722/
https://ncbi.nlm.nih.gov/pubmed/26731412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146466
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