Inhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair

Ionizing radiation (IR) and chemotherapy are standard of care treatments for glioblastoma (GBM) patients and both result in DNA damage, however, the clinical efficacy is limited due to therapeutic resistance. We identified a mechanism of such resistance mediated by phosphorylation of PTEN on tyrosin...

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Publicado no:Cancer Cell
Main Authors: Ma, Jianhui, Benitez, Jorge A., Li, Jie, Miki, Shunichiro, Ponte de Albuquerque, Claudio, Galatro, Thais, Orellana, Laura, Zanca, Ciro, Reed, Rachel, Boyer, Antonia, Koga, Tomoyuki, Varki, Nissi M., Fenton, Tim R., Marie, Suely Kazue Nagahashi, Lindahl, Erik, Gahman, Timothy C., Shiau, Andrew K., Zhou, Huilin, DeGroot, John, Sulman, Erik P., Cavenee, Webster K., Kolodner, Richard D., Chen, Clark C., Furnari, Frank B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6424615/
https://ncbi.nlm.nih.gov/pubmed/30827889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.01.020
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