Targeting intrinsic RIG-I signaling turns melanoma cells into type I interferon-releasing cellular antitumor vaccines

Resistance to cell death and evasion of immunosurveillance are major causes of cancer persistence and progression. Tumor cell-intrinsic activation of the RNA receptor retinoic acid-inducible gene-I (RIG-I) can trigger an immunogenic form of programmed tumor cell death, but its impact on antitumor re...

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Dettagli Bibliografici
Pubblicato in:Oncoimmunology
Autori principali: Bek, Sarah, Stritzke, Florian, Wintges, Alexander, Nedelko, Tatiana, Böhmer, Daniel F.R., Fischer, Julius C., Haas, Tobias, Poeck, Hendrik, Heidegger, Simon
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
Soggetti:
Brief Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422402/
https://ncbi.nlm.nih.gov/pubmed/30906666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1570779
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