Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon–independent apoptosis in human melanoma cells

The retinoic acid–inducible gene I (RIG-I) and melanoma differentiation–associated antigen 5 (MDA-5) helicases sense viral RNA in infected cells and initiate antiviral responses such as the production of type I IFNs. Here we have shown that RIG-I and MDA-5 also initiate a proapoptotic signaling path...

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Bibliographische Detailangaben
Hauptverfasser: Besch, Robert, Poeck, Hendrik, Hohenauer, Tobias, Senft, Daniela, Häcker, Georg, Berking, Carola, Hornung, Veit, Endres, Stefan, Ruzicka, Thomas, Rothenfusser, Simon, Hartmann, Gunther
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719920/
https://ncbi.nlm.nih.gov/pubmed/19620789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37155
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