Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon–independent apoptosis in human melanoma cells

The retinoic acid–inducible gene I (RIG-I) and melanoma differentiation–associated antigen 5 (MDA-5) helicases sense viral RNA in infected cells and initiate antiviral responses such as the production of type I IFNs. Here we have shown that RIG-I and MDA-5 also initiate a proapoptotic signaling path...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Besch, Robert, Poeck, Hendrik, Hohenauer, Tobias, Senft, Daniela, Häcker, Georg, Berking, Carola, Hornung, Veit, Endres, Stefan, Ruzicka, Thomas, Rothenfusser, Simon, Hartmann, Gunther
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2009
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719920/
https://ncbi.nlm.nih.gov/pubmed/19620789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37155
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items