Transient redirection of T cells for adoptive cell therapy with telomerase-specific T helper cell receptors isolated from long term survivors after cancer vaccination

Adoptive cell therapy (ACT) with retargeted T cells has produced remarkable clinical responses against cancer, but also serious toxicity. Telomerase is overexpressed in most cancers, but also expressed in some normal cells, raising safety concerns. We hypothesize that ACT with T-helper cell receptor...

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Publicado en:Oncoimmunology
Autores principales: Kyte, Jon Amund, Fåne, Anne, Pule, Martin, Gaudernack, Gustav
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2019
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422370/
https://ncbi.nlm.nih.gov/pubmed/30906659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1565236
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