Immune response and long-term clinical outcome in advanced melanoma patients vaccinated with tumor-mRNA-transfected dendritic cells

The most effective anticancer immune responses are probably directed against patient-specific neoantigens. We have developed a melanoma vaccine targeting this individual mutanome based on dendritic cells (DCs) loaded with autologous tumor-mRNA. Here, we report a phase I/II trial evaluating toxicity,...

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Библиографические подробности
Опубликовано в: :Oncoimmunology
Главные авторы: Kyte, Jon Amund, Aamdal, Steinar, Dueland, Svein, Sæbøe-Larsen, Stein, Inderberg, Else Marit, Madsbu, Ulf Erik, Skovlund, Eva, Gaudernack, Gustav, Kvalheim, Gunnar
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2016
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5139630/
https://ncbi.nlm.nih.gov/pubmed/27999747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1232237
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