The metastasis suppressor NDRG1 down-regulates the epidermal growth factor receptor via a lysosomal mechanism by up-regulating mitogen-inducible gene 6

The metastasis suppressor, N-Myc downstream-regulated gene-1 (NDRG1) inhibits a plethora of oncogenic signaling pathways by down-regulating the epidermal growth factor receptor (EGFR). Herein, we examined the mechanism involved in NDRG1-mediated EGFR down-regulation. NDRG1 overexpression potently in...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Menezes, Sharleen V., Kovacevic, Zaklina, Richardson, Des R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2019
Aiheet:
Cell Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422098/
https://ncbi.nlm.nih.gov/pubmed/30679310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006279
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