Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity

Aggregation of α-synuclein (αSN) is implicated in neuronal degeneration in Parkinson's disease and has prompted searches for natural compounds inhibiting αSN aggregation and reducing its tendency to form toxic oligomers. Oil from the olive tree (Olea europaea L.) represents the main source of f...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Mohammad-Beigi, Hossein, Aliakbari, Farhang, Sahin, Cagla, Lomax, Charlotte, Tawfike, Ahmed, Schafer, Nicholas P., Amiri-Nowdijeh, Alireza, Eskandari, Hoda, Møller, Ian Max, Hosseini-Mazinani, Mehdi, Christiansen, Gunna, Ward, Jane L., Morshedi, Dina, Otzen, Daniel E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422090/
https://ncbi.nlm.nih.gov/pubmed/30655291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005723
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