Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity

Aggregation of α-synuclein (αSN) is implicated in neuronal degeneration in Parkinson's disease and has prompted searches for natural compounds inhibiting αSN aggregation and reducing its tendency to form toxic oligomers. Oil from the olive tree (Olea europaea L.) represents the main source of f...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mohammad-Beigi, Hossein, Aliakbari, Farhang, Sahin, Cagla, Lomax, Charlotte, Tawfike, Ahmed, Schafer, Nicholas P., Amiri-Nowdijeh, Alireza, Eskandari, Hoda, Møller, Ian Max, Hosseini-Mazinani, Mehdi, Christiansen, Gunna, Ward, Jane L., Morshedi, Dina, Otzen, Daniel E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422090/
https://ncbi.nlm.nih.gov/pubmed/30655291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005723
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