Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity

Aggregation of α-synuclein (αSN) is implicated in neuronal degeneration in Parkinson's disease and has prompted searches for natural compounds inhibiting αSN aggregation and reducing its tendency to form toxic oligomers. Oil from the olive tree (Olea europaea L.) represents the main source of f...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Mohammad-Beigi, Hossein, Aliakbari, Farhang, Sahin, Cagla, Lomax, Charlotte, Tawfike, Ahmed, Schafer, Nicholas P., Amiri-Nowdijeh, Alireza, Eskandari, Hoda, Møller, Ian Max, Hosseini-Mazinani, Mehdi, Christiansen, Gunna, Ward, Jane L., Morshedi, Dina, Otzen, Daniel E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422090/
https://ncbi.nlm.nih.gov/pubmed/30655291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005723
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