24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo

The liver X receptors Lxrα/NR1H3 and Lxrβ/NR1H2 are ligand-dependent nuclear receptors critical for midbrain dopaminergic (mDA) neuron development. We found previously that 24(S),25-epoxycholesterol (24,25-EC), the most potent and abundant Lxr ligand in the developing mouse midbrain, promotes mDA ne...

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Vydáno v:J Biol Chem
Hlavní autoři: Theofilopoulos, Spyridon, Abreu de Oliveira, Willy Antoni, Yang, Shanzheng, Yutuc, Eylan, Saeed, Ahmed, Abdel-Khalik, Jonas, Ullgren, Abbe, Cedazo-Minguez, Angel, Björkhem, Ingemar, Wang, Yuqin, Griffiths, William J., Arenas, Ernest
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422085/
https://ncbi.nlm.nih.gov/pubmed/30655290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005639
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