24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo

The liver X receptors Lxrα/NR1H3 and Lxrβ/NR1H2 are ligand-dependent nuclear receptors critical for midbrain dopaminergic (mDA) neuron development. We found previously that 24(S),25-epoxycholesterol (24,25-EC), the most potent and abundant Lxr ligand in the developing mouse midbrain, promotes mDA ne...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Theofilopoulos, Spyridon, Abreu de Oliveira, Willy Antoni, Yang, Shanzheng, Yutuc, Eylan, Saeed, Ahmed, Abdel-Khalik, Jonas, Ullgren, Abbe, Cedazo-Minguez, Angel, Björkhem, Ingemar, Wang, Yuqin, Griffiths, William J., Arenas, Ernest
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Neurobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422085/
https://ncbi.nlm.nih.gov/pubmed/30655290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005639
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki