Use of transethosomes for enhancing the transdermal delivery of olmesartan medoxomil: in vitro, ex vivo, and in vivo evaluation

INTRODUCTION AND AIM: Olmesartan medoxomil (OLM) is an antihypertensive drug with low oral bioavailability due to extensive first-pass metabolism. This study aimed to prepare transetho somes (TEs) for enhancing the transdermal delivery of OLM to avoid its oral problems. METHODS: TE formulae were pre...

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Vydáno v:Int J Nanomedicine
Hlavní autoři: Albash, Rofida, Abdelbary, Aly A, Refai, Hanan, El-Nabarawi, Mohamed A
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421897/
https://ncbi.nlm.nih.gov/pubmed/30936696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S196771
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